She was also one of the focal points in Morgan Neville's Academy Award-winning documentary "20 Feet from Stardom," which made its world premiere at the 2013 Sundance Film Festival.
Fischer will emerge from the backup-singer shadows when she headlines the St. Regis Big Stars, Bright Nights concert at Deer Valley on Sunday, Aug. 3.
The show will also feature the Muscle Shoals Band, which is comprised of musicians who appeared in another 2013 Sundance Film Festival documentary, "Muscle Shoals," which documented the famed Southern recording studio used by Lynyrd Skynyrd and The Allman Brothers.
Fischer, who called The Park Record from her niece's home on Long lsland, New York, said the show will be comprised of a mix of styles and songs.
"I'm at a stage where I am searching and figuring out what I'll be doing," Fischer confessed. "I want to do songs that I enjoy and songs that I'm familiar with and some songs that I have a history with that I've performed with other groups."
After more than 25 years in the music business, Fischer has plenty of songs to choose from.
"When I started out, I didn't have a clue of what I was going to do," she said. "All I knew was that I loved melodies. I loved the feeling getting lost in those melodies. There was and is something magical about that.
When it came time to record her 1991 debut album "So Intense," which featured the Top 20 single "How Can I Ease the Pain," things fell into place with the help of a good A & R (Artist and Repertoire) representative
"I didn't have a plan, but she got ahold of Michael Walden, Zane Giles, Arif Mardin, Luther Vandross and Raymond Jones, who produced the songs," Fischer said. "The album did show my love for great rhythm & blues music."
Still, throughout her career, Fischer has found security with singing jobs that run the gamut. She tours with the Rolling Stones and sings the main backup to "Gimme Shelter" and is the featured vocalist for Tina Turner.
In 2013, Fischer went metal and toured with Nine Inch Nails.
"I feel like I don't want to be stuck in a single genre," she said. "It's all about the melodies. I just want to be the singer that I am and would like to walk through genres as if I'm visiting different countries. The melodies give me the freedom to do that.
"When I do, I feel like a little chameleon," Fischer explained. "When you work for other people and help them bring their vision to life. You can't show up in shocking pink. You have to be neutral."
However, being good at different styles did pose certain difficulties throughout Fischer's career.
"There were challenges not necessarily as an artist, but in finding direction in the ways the things were done in that time period," she said. "Things feel more open for artists these days. It seems easier for artists to take the journey and not feel like they need to stay with a formula."
Although sharing the stage with some of rock 'n' roll's longstanding icons is definitely a reward, Fischer said her biggest reward comes from being part of an event that becomes a memory for the audience.
"It's not so much the quantity of the work, as it is for the quality of the moment that I work for," she explained. "What I get excited about is watching the artists I work with make the connection. I like seeing the artists kind of through the eyes of the audience as they see something happening on stage.
"It's like when I remember seeing Earth, Wind and Fire 900 years ago," Fischer said with a laugh. "I will never forget that, because the show gave me joy, hope and a release. It also gave me chills up and down my spine. And that was just beautiful."
Today, Fischer makes it a point to do more than just communicate with her audience through the music. She wants them to experience the show.
"It makes life full," she said. "It's much more than watching a concert through a cell phone or sitting at a computer."
The singer also has developed deeper appreciation for her work thanks to "20 Feet From Stardom."
"I didn't see the film until I went to Sundance, so I really didn't know what I was in for," she said. "It has changed my life because it has given me the opportunity to dream, follow that dream and have faith. It has given me a second chance in my career and I'm thankful for that."
The Park City Institute will present Muscle Shoals Live with Lisa Fischer as part of the St. Regis Big Stars, Bright Nights Summer Concerts at Deer Valley's Snow Park Amphitheater on Sunday, Aug. 3, at 7 p.m. Tickets range from $40 to $75 and are available by visiting bigstarsbrightnightsconcerts.org.